• Our understanding of the genetic basis of

  2022-06-27

  

  Our understanding of the genetic basis of myeloid malignancies has been profoundly improved in recent years. Studies have revealed new recurrent somatic mutations in myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML).

• Sometime ago we have described diamino triazines as histamin

  2022-06-27

  

  Sometime ago we have described diamino-1,3,5-triazines as histamine H4R ligands,12, 13 and aryl derivatives of the 1,3,5-triazine, which attenuated inflammatory and nociceptive response in vivo in the rodent models of inflammation induced by telomerase inhibitors and zymosan. In this work we descri

• Successful immune escape will be then followed

  2022-06-27

  

  Successful immune escape will be then followed by cancer development, along with which immunocytes infiltration occurs. While some immunocytes are born to sweep away the malignancy, others aim to neutralize the lethality and sustain immune anergy and tolerance [59,60]. And the latter one is well rep

• Under normal physiological conditions the body has sufficien

  2022-06-27

  

  Under normal physiological conditions, the body has sufficient oxygen supply, so glucose can produce large amounts of ATP by aerobic oxidation and oxidative phosphorylation in cells. After SCI, hypoxia ischemia can occur in local tissue, leading to decreasing of intracellular oxygen partial pressure

• daunorubicin receptor Several studies have found that GPR

  2022-06-27

  

  Several studies have found that GPR55 possesses a distinct pharmacology from that of CB1 and CB2, and that only certain cannabinoids act at this receptor. In transfected daunorubicin receptor expressing hGPR55, out of more than 20 synthetic and endogenous cannabinoids evaluated, only 2 compounds, S

• Dendritic damage and loss of synaptic

  2022-06-24

  

  Dendritic damage and loss of synaptic connections correlate with cognitive decline in HAND patients. Synapse loss induced by HIV proteins occurs early and via a different signaling pathway from that leading to neuronal death (Kim et al., 2008), suggesting that synapse loss might be a mechanism to re

• br Acknowledgements br Introduction Aminoacyl tRNA synthetas

  2022-06-24

  

  Acknowledgements Introduction Aminoacyl-tRNA synthetases catalyze the formation of an ester bond between an amino 3-isomangostin sale and the 3′ end of a tRNA in a two-step reaction. First, the amino acid is activated and an enzyme-bound adenylate intermediate is formed. Then, the amino acid

• Nowadays there is no information if bifunctionality is an ex

  2022-06-24

  

  Nowadays, there is no information if bifunctionality is an exclusive trait of the order Methanococcales or if this characteristic is shared by other orders from archaea, like Methanosarcinales. These organisms are mainly methanogenic, and are not able to use exogenous hexoses as carbon source for ce

• ARCA Cy5 EGFP mRNA receptor Introduction Glucocorticoids are

  2022-06-24

  

  Introduction Glucocorticoids are released in response to stress and play an important role in inflammation, cellular growth, development, body fluid homeostasis, carbohydrate, lipid, and protein metabolism. However, circulating glucocorticoid excess has been associated with a classical phenotype of

• Considerable evidence links sustained GCG administration to

  2022-06-24

  

  Considerable evidence links sustained GCG administration to the reduction of food intake, enhancement of energy expenditure and weight loss in rodent and human studies [16], [17], [18]. Moreover, patients presenting with GCG-producing tumors frequently manifest severe weight loss, through mechanisms

• The potential therapeutic actions of

  2022-06-24

  

  The potential therapeutic actions of GHSR in the central nervous system has been in the limelight lately. Peripheral administration of GHSR agonists have been shown to inhibit oxidative stress, apoptosis, proinflammatory cytokine production, microglia activation, mitochondrial dysfunction, and excit

• Cys loop GABA receptors are well studied

  2022-06-24

  

  Cys-loop GABA receptors are well-studied targets for insecticides and also play an important role in nematode biology. These receptors are also targets for the anthelmintic piperizine (Accardi et al., 2012). The nematode GABA receptor most studied is the UNC-49 receptor which plays a role in muscle

• The effect of on the conformational of G quadruplexes was

  2022-06-24

  

  The effect of on the conformational of G-quadruplexes was investigated with circular dichroism (CD) spectroscopy. In the absence of , the CD spectra of parallel G-quadruplex exhibited a characteristic positive peak at about 265 nm, and a negative peak at about 240 nm; antiparallel G-quadruplex sh

• The regulatory effects of NADPH oxidase on ferroptosis might

  2022-06-24

  

  The regulatory effects of NADPH oxidase on ferroptosis might also relate to neuroinflammation. Although ferroptosis can trigger inflammatory responses in the brain, neuroinflammation, in turn, can also modify ferroptosis. It has been reported that inflammatory conditions such as those found in neuro

• br Characterization of quantal exocytosis by amperometry A s

  2022-06-24

  

  Characterization of quantal exocytosis by amperometry A secretory vesicle experiences four phases during exocytosis: (i) cargo packaging & translocation, (ii) vesicle docking & priming; (iii) fusion pore formation; (iv) fusion pore expansion and cargo secretion (Fig. 1a). The release of monoamine

14376 records 395/959 page Previous Next First page 上5页 391392393394395 下5页 Last page