• GSTP has an antiapoptotic activity that is

  2022-04-18

  

  GSTP1 has an antiapoptotic activity that is mediated by the inhibitory interaction with JNK1. Our data suggest that GSTP1 treatment is associated with a significant down-regulation of caspase expression. This might explain the reduction in infarct-related cardiomyocyte death and saving the cardiomyo

• Hypoxia has been shown to affect miR

  2022-04-18

  

  Hypoxia has been shown to affect miR-155 expression that can induce autophagy in nasopharyngeal and cervical carcinoma cells [334]. Suppression of miR-155 inhibited hypoxia-induced autophagy. miR-155 targeted mRNAs involved in the PI3K/PTEN/Akt/mTORC1 pathway including: Ras homolog enriched in EPZ03

• br Conclusion br Conflict of interest br References and reco

  2022-04-18

  

  Conclusion Conflict of interest References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Free fatty acids (FFAs) are essential nutrients that contribute to various cellular functio

• The recently de orphaned G

  2022-04-18

  

  The recently de-orphaned G-protein coupled receptor (GPCR), GPR55, is activated endogenously by L-α-lysophosphatidylinositol (LPI), a lipid signaling molecule, as well as N-arachidonoyl glycine (NAGly) and numerous endo, phyto, and synthetic cannabinoids (Oka et al., 2007, Henstridge et al., 2010, H

• Because of its excellent GPR potency good hERG

  2022-04-18

  

  Because of its excellent GPR119 potency, good hERG selectivity and favorable rat t, harmine was scaled-up and further profiled. The synthetic protocols described in , were both suitable for a multi-gram scale synthesis of compound . An off-target screen was performed against an extensive panel of

• The facts mentioned above indicate that

  2022-04-18

  

  The facts mentioned above indicate that glycine function in brain is tightly regulated or pathologically altered mostly by glycine transporters. Modification of cytosolic regions of transporters, which interconnect them with intracellular regulatory pathways, could be one of the ways to provoke brai

• The inhibition of NSAIDs towards

  2022-04-18

  

  The inhibition of NSAIDs towards GLOI provides a direction for the development of novel effective GLOI inhibitors. Although the inhibitory activity of indomethacin was determined and the interactions between it Oxipurinol mg and GLOI were probed by NMR titration experiments, no detailed inhibitory

• Morin is a flavonoid that

  2022-04-18

  

  Morin is a flavonoid that has shown to have effective anti-inflammatory and anti-tumor function [118]. Morin was able to block the activation of NF-κB pathway by ROS and inflammatory cytokines, preventing a signaling cascade resulting in cell death [121]. Morin exerted its control over the signaling

• Our supF forward mutation assay revealed

  2022-04-18

  

  Our supF forward mutation assay revealed, for the first time, that 5OHU predominantly induced the C→T mutation in human cells. The mechanism underlying the induction of the C→T mutation in human cells by 5OHU remains unclear, however, the finding that 5OHU predominantly induced the C→T mutation was

• br Results br Discussion br Materials and

  2022-04-18

  

  Results Discussion Materials and Methods Introduction Deoxyribonucleic Cl-Amidine trifluoroacetate salt (DNA) is among the most important biopolymers in living organisms alongside carbohydrates and proteins. DNA is a linear polymer consisting of four types of nucleobases, deoxyribose, a

• Several reports have shown that the

  2022-04-18

  

  Several reports have shown that the ICD of CLRs is involved in the desensitization process of this superfamily. The analysis of our chimeric constructs between GlyRα1 and GLIC revealed differences in desensitization properties. In contrast, other ion channel properties such as channel block and ion

• MRcKO mice showed a comparable degree of

  2022-04-18

  

  MRcKO mice showed a comparable degree of cardiac remodeling compared to control (MRf/f) mice. Moreover, the worse cardiac remodeling in pressure-overloaded GRcKO mice is not due to compensatory activation of cardiomyocyte MR, because GRMRdcKO mice displayed cardiac remodeling to the same extent as G

• Emerging evidence has shown that pharmacological FXR agonism

  2022-04-18

  

  Emerging evidence has shown that pharmacological FXR agonism attenuates chronic alcohol treatment-induced liver injury and steatosis [18], [19], while whole-body FXR knockout worsens alcohol-induced liver injury [19]. This suggests that FXR plays an important role in ALD development. However, defici

• All data were analyzed using

  2022-04-18

  

  All data were analyzed using SAS software (version 9.3, SAS Institute Inc., Cary, NC). Because of very low FFAR1 protein detection (at the detection limit or no signal) in 3 H-BHB cows, quantification was not possible within a linear range and therefore these animals were omitted from the statistica

• br Acknowledgement The authors are grateful

  2022-04-16

  

  Acknowledgement The authors are grateful for financial support provided from specific university research (MSMT No 21-SVV/2018). Introduction Several recent studies have demonstrated that planaria, flatworms notable for their regenerative capabilities, can develop conditioned place preference

14058 records 412/938 page Previous Next First page 上5页 411412413414415 下5页 Last page