• Some previous findings indicate that

  2021-10-18

  

  Some previous findings indicate that GALP has an influence on AVP and OT secretion from the posterior pituitary gland. Cunningham et al. (2004) noted that the expression of GALP mRNA was increased in the neurohypophysis of lactating rats compared to non-lactating rats, whereas GALP mRNA expression i

• An advantage of photolabeling with

  2021-10-18

  

  An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled leonurine and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric interactions with other li

• The effect of GC on Fgf

  2021-10-18

  

  The effect of GC on Fgf21 was not directly dependent on ileal Fgf15 because basal Fgf21 GW788388 was similar in Fgf15+/+ and Fgf15−/− mice. Moreover, GC treatment induced similar Fgf21 up-regulation in both strains. Fxr activation has been reported to increase Fgf21 expression and secretion [28]. I

• Hydantoin in region F bridging the phenoxybenzene

  2021-10-18

  

  Hydantoin in region F bridging the phenoxybenzene and benzimidazole moieties was replaced by cyclic building blocks, diketopiperazine (25) and imidazolidinone (26), and linear bonds, amide (27) and urea (28). Analogs 25–28 possessing the linkers other than hydantoin were not tolerated in LBD of FXR,

• tetracaine hydrochloride synthesis We used a culture model o

  2021-10-16

  

  We used a culture model of human erythropoiesis that recapitulates all developmental stages [24] to screen a focused set of lncRNAs for potential contribution to this program. We found induction of lncRNA Fas-antisense 1 (Fas-AS1 or Saf) during RBC maturation and demonstrate that essential erythroid

• Dysregulation of the HPA axis resulting

  2021-10-16

  

  Dysregulation of the HPA axis, resulting in alteration to both baseline and stress-induced glucocorticoid levels (e.g., cortisol and corticosterone), has been implicated in several diseases and psychopathologies, including anxiety (McEwen et al., 2015, 2016; Shin and Liberzon, 2010). For example, ba

• CTGF is an established YAP TAZ target gene which plays

  2021-10-16

  

  CTGF is an established YAP/TAZ target gene which plays a central role in tissue remodeling. Downregulation of CTGF mediates collagen loss in chronologically-aged human skin whereas persistent activation of CTGF can result in excessive deposition of collagen and fibrotic disorders [63]. The authors f

• A nitric oxide donor glyceryl trinitrite and the

  2021-10-16

  

  A nitric oxide donor, glyceryl-trinitrite, and the substrate for nitric oxide, l-arginine, have been used to treat preterm labor. However, these studies are preliminary. The beneficial effect of nitric oxide donors needs to be confirmed by more controlled studies. The probable pitfall of using nitri

• Several studies have proposed that high

  2021-10-16

  

  Several studies have proposed that high levels of KYNA in the Ch 55 contribute to cognitive dysfunctions presented by patients who suffer from schizophrenia [30], [31], [32], [33]. Considering that: (i) KYNA is a known GPR35 agonist [2], (ii) cognitive impairments in patients with schizophrenia and

• npy receptor G protein coupled receptor GPCR ligands can be

  2021-10-16

  

  G-protein-coupled receptor (GPCR) ligands can be classified as either orthosteric or allosteric modulators. Orthosteric and endogenous ligands bind to the same site, which is topologically distinct from the allosteric site. In general, the binding domains of different orthosteric ligands may not exa

• The results of our study indicate the

  2021-10-16

  

  The results of our study indicate the general importance of the gp120 V3 loop citric acid patch in the subunit association of primate immunodeficiency virus Env trimers. Our observation that the stem insertion mutants and hydrophobic patch mutants exhibit similar phenotypes with respect to gp120 sh

• The soluble receptor for advanced glycation

  2021-10-16

  

  The soluble receptor for advanced glycation end products has been already studied in physiological and pathological pregnancy. In accordance to our previous studies we showed increased sRAGE serum levels in women with threatening premature labor [15] and we described a negative correlation of sRAGE

• Among the various delivery strategies

  2021-10-16

  

  Among the various delivery strategies in the field of nano-DDS, developing smart targeted nanocarriers has long been a research focus for pharmaceutical scientists11., 12.. The ideal drug delivery outcome must be precisely delivering the therapeutic agents to their sites of action, especially for an

• 5-fluorocytosine sale The dopamine substrate currents IDA IC

  2021-10-16

  

  The dopamine substrate currents (IDA – IControl) were determined at different holding potentials (IV curves) in transfected HT22 cells (Fig. 5A). The plot for HT22 cells transfected with DAT exhibited the typical behavior of dopamine transporter currents (Ingram et al., 2002; Sonders et al., 1997),

• Cortisol targets many organs and tissues and

  2021-10-16

  

  Cortisol targets many organs and tissues and has certain effects on metabolism, including promoting glycolysis. It can cross the blood abt 199 barrier and act centrally to regulate HPA axis activity by activating negative feedback mechanisms effectively, cortisol inhibits its own production (Fairch

14058 records 523/938 page Previous Next First page 上5页 521522523524525 下5页 Last page