• Many studies have found that

  2021-06-04

  

  Many studies have found that there is an aberrant DNA methylation in the imprinting control region of development-related genes in the spermatozoa of oligozoospermic men (Kobayashi et al, 2007, Marques et al, 2004, Marques et al, 2008), which most likely results from expressional changes in the DNMT

• For in vitro expression analysis of CXCL and CXCRs by

  2021-06-03

  

  For in vitro expression analysis of CXCL8 and CXCRs by stimulated leucocytes, peripheral blood leucocytes (PBLs) were isolated using Percoll density gradient centrifugation as described earlier . Cell suspensions were adjusted to 5×10/ml. Four milliliters of tissue culture medium were plated per wel

• br Acknowledgement br Introduction Recent developments in ca

  2021-06-03

  

  Acknowledgement Introduction Recent developments in cancer immunotherapies have demonstrated durable responses, suggesting that effective immunotherapy would hold promise to improve patient outcome (Gunturu et al., 2013; Hodi et al., 2003; Lutz et al., 2011; Ribas et al., 2009). However, attem

• The pyrrolo benzodiazepines PBDs are

  2021-06-03

  

  The pyrrolo[2,1-][1,4]benzodiazepines (PBDs) are a family of antitumour antibiotics that includes the natural products anthramycin and DC-81. They exert their cytotoxicity by covalently bonding to the exocyclic C2–NH group of guanine residues in the minor groove of DNA through their N10–C11 imine fu

• br The modulation of ER from SERMs

  2021-06-03

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective Protein A/G receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinity, despi

• Costunolide synthesis br Conflict of interest br Supplementa

  2021-06-03

  

  Conflict of interest Supplementary methods and materials Acknowledgments This work was supported by an Early Career Researcher grant awarded by the Institute of Health and Biomedical Innovation to IMW and Queensland University of Technology, and grants awarded to SS by the Prostate Cancer F

• br Materials and methods br Results br

  2021-06-03

  

  Materials and methods Results Discussion DAS and nilotinib, as the second potent, oral generation TKIs, bind to both the active and inactive conformation of the ABL1 kinase domain, have been found to be effective in treating patients with IM resistant or intolerant CML-CP, and inhibit all t

• p2x7 receptor br Materials and methods br Results br Discuss

  2021-06-03

  

  Materials and methods Results Discussion In particular, we showed that pancreatic neuroendocrine tumor p2x7 receptor recognize cAMP as a stimulatory signal for cell proliferation. Conversely, cAMP was found to have an inhibitory effect on cell proliferation in bronchial carcinoids cells. T

• Perhexiline maleate br Disclosures br Acknowledgements This

  2021-06-03

  

  Disclosures Acknowledgements This work was supported by the Natural Science Foundation of China (No. 81560587); the Fok Ying-Tong Education Foundation of China (No. 151107), the basic ability promotion project for young and middle-aged teachers in Universities in Guangxi (No. 2018KY1146) and t

• As with all meta analysis

  2021-06-03

  

  As with all meta-analysis, this study certainly has some limitations. First, our results were derived from unadjusted analyses due to lack of raw data, and lack of further adjusted analyses for age, gender and co-morbidity conditions may impact the reliability of our findings [63]. Second, obvious h

• Enolases are among the most abundantly expressed

  2021-06-03

  

  Enolases are among the most abundantly expressed cytosolic proteins. They are metalloenzymes that catalyze the conversion of 2-phosphoglycerate to phosphoenolpyruvate [18]. Eubacteria and archaebacteria have a single enolase gene (reviewed in [19]). Despite the lack of signal peptides or cognate pro

• Several molecular differences between visceral and subcutane

  2021-06-03

  

  Several molecular differences between visceral and subcutaneous adipose tissue have been described. One of the most demarcating differences between adipose depots is the signature of developmental genes, including Hox, Shox, and T-box genes [12], [13]. Lineage tracing studies have revealed key devel

• From these and other studies it is clear

  2021-06-03

  

  From these and other studies, it is clear that acriflavine is an interesting dna alkylating agents with pleiotropic anticancer effects [21], [22], [43]. Its past systemic use in the clinical setting as an antibiotic without any major toxicity reported encourages further development of the drug for

• The modification of proteins with

  2021-06-03

  

  The modification of proteins with the small 76-amino Bufalin protein ubiquitin (Ub) plays a central role in many key cellular processes. Ubiquitylation of a target protein requires the concerted action of a cascade of three enzymes (Figure 1). The ubiquitin-activating enzyme (E1) catalyzes the forma

• ATRX belongs to the switch sucrose

  2021-06-03

  

  ATRX belongs to the switch/sucrose non-fermenting (SWI/SNF) chromatin remodeling family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression (Gibbons et al., 1995). Most of these mutations are located in two highly conserved regions of the ATRX protein: a

14376 records 626/959 page Previous Next First page 上5页 626627628629630 下5页 Last page