• Downregulation of tumor suppressors is

  2021-04-25

  

  Downregulation of tumor suppressors is a major factor that leads to tumorigenesis. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a common tumor suppressor, the mCAP of which is often downregulated or even absent in the majority of human cancers, functions as a phosphatase to dephos

• Modulating protein stability specifically inhibiting ubiquit

  2021-04-25

  

  Modulating protein stability, specifically inhibiting ubiquitin E3 ligases, provides potential advantages over other druggable targets given the presence of biochemically multiple, unique pharmacophores within complexes that can bind a variety of small molecules [12]. The FBXO3 inhibitors used here

• Recent results from our group found that SPMs

  2021-04-25

  

  Recent results from our group found that SPMs, not only play a part in terminating inflammation, but also have a physiological role in conjunctival goblet 8-Methoxypsoralen to maintain ocular surface health in the absence of disease. Amongst the SPMs that are effective in the conjunctiva are resolv

• Introduction Amphetamine AMPH methamphetamine MA and

  2021-04-25

  

  Introduction Amphetamine (AMPH), methamphetamine (MA), and 3,4-ethylenedioxymethamphetamine (MDMA) are widely abused psychoactive substances, with the basic chemical structure of phenylethylamine [1]. The abuse of these drugs is associated with psychostimulant, anorectic and hallucinogenic properti

• ApicomplexansApicomplexans are unicellular and spore forming

  2021-04-25

  

  ApicomplexansApicomplexans are unicellular and spore-forming obligate intracellular parasites that occupy diverse host niches (Mogi and Kita 2010). They have remodeled mitochondrial carbon and energy metabolism through reductive evolution. The development of novel drugs is now a very serious challen

• br Cytokines and NK cells br Combined effects of

  2021-04-25

  

  Cytokines and NK cells Combined effects of cytokines and other stimuli on NK cell function Cytokine-stimulated NK nm osi have enhanced capacity to kill tumor cells. However, usually, individual cytokines do not seem to be sufficient for full activation, proliferation, survival and effector fu

• Trk receptors critically support the development and

  2021-04-25

  

  Trk receptors critically support the development and maintenance of the nervous system, , but their over-expression in various neural and non-neural neoplasms such as breast, pancreatic, lung and neuroendocrine tumors also confers aggressive phenotypes to tumor benzydamine and correlates with poor p

• Following mutagenesis of the glucarpidase gene of

  2021-04-25

  

  Following mutagenesis of the glucarpidase gene of Pseudomonas sp. strain RS-16 [30], approximately 73% of the clones retained enzyme activity, as indicated by the clear zones and yellow precipitate surrounding their colonies. However, there were very few that had ‘halos’ around colonies that were da

• Stable isotope studies applied to skeletal remains of

  2021-04-25

  

  Stable isotope studies, applied to skeletal remains of early Pacific populations, have shown a trend toward a horticultural diet with temporal variation in response to local environmental conditions (Field et al., 2009; Kinaston and Buckley, 2013; Valentin et al., 2010, Valentin et al., 2014; Kinast

• The current study had the following

  2021-04-25

  

  The current study had the following 3 aims: Materials and methods Results Discussion Western Europe, USA/Canada, and Australia have traditionally been the areas in which cochlear desogestrel is most common [9], [10]; correspondingly, the most common and well-known validated tests and (re)

• br Methods br Results br Discussion I

  2021-04-25

  

  Methods Results Discussion I/R induces oxidative stress and increases the intracellular levels of ROS, resulting in tissue damage [31]. ROS is generated by mitochondrial electron transport chain, nicotinamide corticosterone receptor dinucleotide phosphate (NADPH) oxidase complex, xanthine

• br Transparency document br Acknowledgments This study was f

  2021-04-25

  

  Transparency document Acknowledgments This study was funded by ICMR, Govt. of India. Alisha Dhiman acknowledges UGC-DSKPDF, India for post-doctoral fellowship and Monisha Gopalani acknowledges CSIR, India for Senior Research Fellowship. AIRF, JNU is acknowledged for TEM, confocal microscopy an

• br Conflict of interest statement br Introduction Endothelin

  2021-04-25

  

  Conflict of interest statement Introduction Endothelins (ETs) are a family of multifunctional, naturally occurring peptides with long-lasting vasoconstrictor and pressor effects (Zhou et al., 2004). They are synthesized as a large protein, the pre-proET-1 or Big ET-1, which is subsequently cle

• Three kinase inhibitors dasatinib type I

  2021-04-25

  

  Three kinase inhibitors dasatinib (type I), imatinib (type II) and nilotinib (type II), identified initially as inhibitors of tyrosine kinase BCR-ABL, were found to target DDRs in a chemical proteomic profiling study (Bantscheff et al., 2007, Hantschel et al., 2008). These tyrosine kinase inhibitors

• br Acknowledgements We thank Dr Tai Yuan Yu and

  2021-04-23

  

  Acknowledgements We thank Dr. Tai-Yuan Yu and Miss Chun-Ping Chang for helping with the drug/DNA sequence specificity study. We also thank the Chemical Synthesis Core and the Pathology Core Laboratory of IBMS for synthesizing SL-1 and for performing the pathology analysis, respectively, and the T

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