• br Materials and methods br Results br Discussion In this

  2019-09-16

  

  Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated citric acid guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimulated by both LTC4 and LTD

• MicroRNA (miRNA) is a class of highly conserved

  2019-09-12

  MicroRNA (miRNA) is a class of highly conserved, non-coding small molecules containing 19–25 nucleotides. miRNAs are involved in the regulation of genes associated with cancer development and progression and therefore can act as oncogenes

• Among the different factors that modulate

  2019-09-11

  Among the different factors that modulate Schwann cell biology, several studies pointed out the role played by neuroactive steroids, in particular progesterone (P4) and its derivatives dihydroprogesterone (DHP) and allopregnanolone (ALLO).

• Our study provides proof of principle for dimerizing

  2019-09-10

  Our study provides proof of principle for dimerizing two different E3 ligases as a novel approach to inducing one ligase to degrade the other one. The outcome of ‘ligase versus ligase’ PROTAC-mediated activity might be unpredictable a priori, but could reveal a new mechanism for proximity-mediated hijacking between E3 ligases.

• Adding MPA or NETA we found no impact

  2019-09-09

  Adding MPA or NETA we found no impact on the estradiol-induced downregulation of serum-stimulated endothelin synthesis in vitro [40]. Progesterone was also able to inhibit the angiotensin II-induced increase in endothelin production [41].

• Ubiquitin-activating enzyme activates ubiquitin by

  2019-09-07

  Ubiquitin-activating enzyme activates ubiquitin by a three-step process with ATP as a cofactor (Chen et al., 2011, Haas and Rose, 1982, Haas et al., 1982).

• In the present study promoting bile ST 2825

  2019-09-06

  In the present study, promoting bile ST 2825 synthesis by activating EP4 receptors was shown to exert protection against hepatic steatosis.

• Enolase is an example of a moonlighting protein

  2019-09-05

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties.

• Discussion The present study shows that

  2019-09-04

  Discussion The present study shows that peripheral administration of the nonpeptidic corticotropin-releasing factor CRF1 receptor antagonist CP-154,526 before a social defeat inhibits the development of CPP induced with a subthreshold dose of cocaine and reverses the effects of social defeat on motor sensitization.

• Introduction Fish commonly employ pheromones

  2019-09-03

  Introduction Fish commonly employ pheromones to regulate a variety of functions including reproductive communication [1].

• Natural and synthetic glucocorticoids perform

  2019-09-02

  Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors).

• Likewise the conserved cysteine

  2019-08-30

  Likewise, the conserved cysteine in the E2 protein is the only residue shown to be essential for the transfer of Ub/Ubl from E2 to the HECT ligases (Dye and Schulman, 2007, Wu et al., 2003).

• Our data also showed that D2 dopamine

  2019-08-29

  Our data also showed that D2 dopamine receptor was down-regulated in the hippocampus, NAc and striatum of F1-MEP animals, which was only significant in the hippocampus. Both agonists and antagonists of D2 dopamine receptor are able to decrease heroin self-administration (Hemby et al., 1996; Rowlett et al., 2007).

• Acknowledgments The authors wish to

  2019-08-28

  Acknowledgments The authors wish to thank P. Costet (University of Bordeaux) and Véronique Guyonnet-Duperat (FR TransBioMed, Plateforme de Vectorologie, University of Bordeaux) and Prof.

• Estrogen receptors activate mGluR

  2019-08-27

  Estrogen receptors activate mGluR signaling pathways In order to distinguish the opposing effects of estradiol on CREB phosphorylation, we turned to a “bottom-up” approach, working backwards from CREB phosphorylation to pharmacologically isolate the two signaling pathways (Boulware et al., 2005).

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