• Enolase is an example of a moonlighting protein

  2019-09-05

  Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties.

• Discussion The present study shows that

  2019-09-04

  Discussion The present study shows that peripheral administration of the nonpeptidic corticotropin-releasing factor CRF1 receptor antagonist CP-154,526 before a social defeat inhibits the development of CPP induced with a subthreshold dose of cocaine and reverses the effects of social defeat on motor sensitization.

• Introduction Fish commonly employ pheromones

  2019-09-03

  Introduction Fish commonly employ pheromones to regulate a variety of functions including reproductive communication [1].

• Natural and synthetic glucocorticoids perform

  2019-09-02

  Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors).

• Likewise the conserved cysteine

  2019-08-30

  Likewise, the conserved cysteine in the E2 protein is the only residue shown to be essential for the transfer of Ub/Ubl from E2 to the HECT ligases (Dye and Schulman, 2007, Wu et al., 2003).

• Our data also showed that D2 dopamine

  2019-08-29

  Our data also showed that D2 dopamine receptor was down-regulated in the hippocampus, NAc and striatum of F1-MEP animals, which was only significant in the hippocampus. Both agonists and antagonists of D2 dopamine receptor are able to decrease heroin self-administration (Hemby et al., 1996; Rowlett et al., 2007).

• Acknowledgments The authors wish to

  2019-08-28

  Acknowledgments The authors wish to thank P. Costet (University of Bordeaux) and Véronique Guyonnet-Duperat (FR TransBioMed, Plateforme de Vectorologie, University of Bordeaux) and Prof.

• Estrogen receptors activate mGluR

  2019-08-27

  Estrogen receptors activate mGluR signaling pathways In order to distinguish the opposing effects of estradiol on CREB phosphorylation, we turned to a “bottom-up” approach, working backwards from CREB phosphorylation to pharmacologically isolate the two signaling pathways (Boulware et al., 2005).

• By using the C elegans Matrisome Annotator

  2019-08-26

  By using the C. elegans Matrisome Annotator tool, we found substantial enrichment for matrisome Ibuprofen in these data sets. Thus, re-analyzing -omic datasets with the C.

• Acknowledgements We thank Dr. James Ritchie and

  2019-08-24

  Acknowledgements We thank Dr. James Ritchie and his dedicated staff (Deptartment of Pathology, Emory University) for performing measures of serum VPA levels; Sumitomo Pharmaceuticals (Osaka, Japan) for the generous donation of DOPS, which is required for breeding Dbh −/− mice; Pfizer (Sandwich, Kent, UK) for their generous donation of reboxetine; Z. Donaldson, P. Kirkland, and M. Marino for technical assistance. This project was supported by the Epilepsy Foundation.

• Chk1 and Chk2 are functionally redundant

  2019-08-23

  Chk1 and Chk2 are functionally redundant protein kinases that respond to checkpoint signals emanating from the phosphatidylinositol 3-kinase family members ATM (ataxia-telangiectasia mutated) and ATR (Ataxia-telangiectasia and Rad-3 related).

• To our knowledge immunohistochemical analysis

  2019-08-22

  To our knowledge, immunohistochemical analysis for proGRP was done in 5 cases [9], [10], [17], [18]. Takagi-Takahashi et al. reported that the tumor Birinapant were positive for proGRP in one case [9].

• The development of C797S mutation has been

  2019-08-21

  The development of C797S mutation has been reported in vivo in a small cohort (15 subjects) of EGFR T790M positive patients progressing after Osimertinib: this tertiary mutation was found, using a droplet digital PCR (ddPCR) assay, in 40% of patients after AR to this agent, while 33% of the cases exhibited persistence of the secondary mutation T790M (without C797S) and 27% showed neither T790M nor C797S mutations (Thress et al., 2015).

• We propose two hypotheses to interpret

  2019-08-20

  We propose two hypotheses to interpret our findings. The first, ELR (+) CXC chemokines stimulate both CXCR-1 and CXCR-2 chemokine receptor while activating neutrophils; however CXCR-1 chemokine receptor seems to play more active role in the process of neutrophil migration as shown in previous studies [9], [18], [24], [25], [26].

• CDK Regulators as Coactivators of NF-κB

  2019-08-19

  CDK Regulators as Coactivators of NF-κB and STAT CDK regulating proteins also have the ability to control the inflammatory response.

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