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ABT-737: Leveraging BH3 Mimetic Inhibitors for Targeted A...
2025-09-22
Explore the mechanistic and translational aspects of ABT-737, a potent BH3 mimetic inhibitor and small molecule BCL-2 protein inhibitor, focusing on its role in apoptosis induction and cancer research models such as lymphoma, multiple myeloma, SCLC, and AML.
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Optimizing Recombinant Protein Purification with FLAG tag...
2025-09-19
Explore the scientific principles and practical strategies for maximizing recombinant protein purification using the FLAG tag Peptide (DYKDDDDK). This article discusses peptide solubility, affinity elution, and real-world applications in advanced protein research.
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Pioglitazone and PPARγ Activation: New Insights into Infl...
2025-09-18
Explore how Pioglitazone, a selective PPARγ agonist, modulates macrophage polarization and inflammatory responses via the STAT-1/STAT-6 pathway, providing novel perspectives for type 2 diabetes mellitus research and inflammatory disease models.
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The current guidelines are designed to optimize the
2025-03-03
The current guidelines are designed to optimize the detection of IHC+FISH+ cases, most of which (but not all encountered in our study) being classically good responders to crizotinib therapy (resistance mechanisms to crizotinib therapy were not investigated in our study). In addition to the current
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FDA-approved Drug Library Considering our previous results w
2025-03-03
Considering our previous results with cfDNA in EGFR TKI-resistant NSCLC patients and growing evidence about different mutations in the ALK kinase domain as responsible for acquired resistance to ALK TKIs, we planned this study. Even if a next-generation sequencing approach after PD during crizotini
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Therefore to better understand the
2025-03-03
Therefore, to better understand the functional properties of Peruvian infusion tea plants and provide evidence for the development of functional food supplements containing the Peruvian infusion tea plant, the aldose reductase inhibition together with the antioxidant activities of 24 selected Peruvi
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AR is an enzyme involved in conversion of
2025-03-03
AR is an enzyme involved in conversion of glucose into sorbitol using NADPH as a cofactor [46]. This AR polyol pathway generates sorbitol accumulation and NADPH depletion. NADPH participates in detoxification via glutathione (GSH) reductase pathway [47]. Therefore, reduction of NADPH attenuates remo
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Additionally we were prompted to validate the
2025-03-03
Additionally, we were prompted to validate the protective effect of ALDH3A1 by utilizing a human corneal model. Cornea is located in the anterior segment of the eye and thus, is constantly exposed to various environmental stressors that affect the cellular oxidative balance and consequently lead to
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Analyses of brain CSCs isolated from
2025-03-03
Analyses of receptor tyrosine kinase CSCs isolated from 24 pediatric and six adult brain tumors detected ALDH levels proportional to tumor type and aggressiveness. ALDH-expressing cells (ALDH+) formed spheroids while ALDH1 pharmacological inhibition by a combination of DEAB and RA decreased signifi
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br There are three types
2025-03-03
There are three types of 5-HT2 receptors. 5-HT2A, 5-HT2B and 5-HT2C receptors Exhibit 46–50% overall sequence identity and couple preferentially to Gq/11 to increase inositol phosphates and cytosolic [Ca2+] and in agreement with their long known role in muscle contraction and stimulation in the br
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The potential use of derivatives belonging to
2025-03-03
The potential use of derivatives belonging to this series as therapeutic agents mostly depends on their pharmacokinetics and pharmacodynamics. The pharmacokinetic phase includes absorption, distribution, metabolism and excretion (ADME) of the studied compounds. Therefore, preliminary data for theore
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Adenosine is a ubiquitous homeostatic purine
2025-03-03
Adenosine is a ubiquitous homeostatic purine nucleoside that accumulates extracellularly in response to metabolic stresses such as hypoxia and inflammation. Activation of either G protein-coupled adenosine receptors (ARs; A1R, A2AR, A2BR, and A3R) by extracellular adenosine can modulate cell signali
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Some alterations in the integrity
2025-03-03
Some alterations in the integrity of cell membranes caused by toxic agents can be determined by measuring certain enzymes released by damaged cells [8]. The cholinesterases, for example, catalyze the hydrolysis of Condensed tannin (ACh) in choline and acetic acid. Theses enzymes are divided into tw
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Given these findings above we hypothesized
2025-03-03
Given these findings above, we hypothesized that hypernociception produced by intra-amygdala 8-OH-DPAT is result of hyperpolarization in this area. This neuronal inhibition of the amygdaloid complex might result in an inactivation of crucial neurotransmitter systems of the descending inhibitory pain
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Moreover showed reduction in fibroblast growth factor induce
2025-03-03
Moreover, showed 73% reduction in fibroblast growth factor–induced neovascularization in a mouse corneal micropocket assay at a dose of 100mg/kg and 50% reduction at 50mg/kg. Both results were highly statistically significant (Panti-Axl IMR-1 have recently shown only moderate efficacy (40% inhibit